News
OPUS grant by National Science Center accepted: Novel broad-spectrum central nervous system active substances: optimization oftheir multi-target profile.
Prof. Agnieszka A. Kaczor guest edits a special issue of International Journal of Molecular Sciences entitled "Multi-Target Ligand Design for Potential Antipsychotic". Submission deadline: June 1st, 2022.
Prof. Agnieszka A. Kaczor became an editorial board member of Frontiers in Bioscience-Landmark and guest edits a special issue entitled "New perspectives for treatment of mental and neurodegenerative diseases". Submission deadline: May 31st 2022.
Prof. Agnieszka A. Kaczor is an editor of a book within Methods in Molecular Biology book series, published by Springer Nature.
PRACE (Partnership for Advanced Computing in Europe) grant "Molecular simulations of drug targets involved in the central nervous system diseases (NERVOMOLSIM)" accepted.
Prof. Agnieszka A. Kaczor invited to contribute to Early-Career Special Collection: EuroMedChem Talents (special issue of ChemMedChem).
Prof. Agnieszka A. Kaczor became a member of Molecules Editorial Topic Board. Submissions to Special Issue entitled "Targeting Signaling Complexity of GPCRs for the Treatment of CNS Diseases" are now invited. Submission deadline: June 30th, 2022.
OPUS grant by National Science Center accepted: Novel multi-target ligands of aminergic GPCRs as pharmacological tools to study the pathomechanism of schizophrenia.
OPUS grant by National Sciennce Center in consortium with University of Life Sciences in Lublin (leader) and University of Rzeszow accepted: Dietary polyphenols as thyroid peroxidase (TPO) modulators with multidirectional biological activity - a combined in vitro and in silico investigations.
New articles
Magda Kondej, Tomasz M. Wrobel, Katarzyna M. Targowska-Duda, Anton L. Martinez, Oliwia Koszla, Piotr Stepnicki, Agata Zieba, Alba Paz, Olga Wronikowska-Denysiuk, Maria I. Loza, Marian Castro, Agnieszka A. Kaczor: Multi-target derivatives of D2AAK1 as potential antipsychotics - the effect of the substitution in the indole moiety. ChemMedChem 2022, in press.
Agata Zieba, Piotr Stepnicki, Dariusz Matosiuk, Agnieszka A. Kaczor: What are the challenges with multi-targeted drug design for complex diseases? Expert Opin. Drug Discov. 2022, in press.
Agata Bartyzel, Agnieszka A. Kaczor, Ghodrat Mahmoudi, Ardavan Masoudiasl, Tomasz M. Wrobel, Monika Pitucha, Dariusz Matosiuk: Experimental and computational structural studies of 2,3,5-trisubstituted and 1,2,3,5-tetrasubstituted indoles as non-competitive antagonists of GluK1/GluK2 receptors. Molecules 2022, 27, 2479.
Oliwia Koszla, Przemyslaw Solek, Piotr Stepnicki, Agnieszka A. Kaczor: Screening and structure-activity relationship of D2AAK1 derivatives for potential application in the treatment of neurodegenerative diseases. Molecules 2022, 27, 2239.
Oliwia Koszla, Przemyslaw Solek, Ewa Kedzierska, Piotr Listos, Marian Castro, Agnieszka A. Kaczor: In vitro and in vivo evaluation of antioxidant and neuroprotective properties of antipsychotic D2AAK1. Neurochem. Res. 2022, 47, 1778-1789.
Justyna Zuk, Damian Bartuzi, Przemyslaw Miszta, Agnieszka A. Kaczor: The role of lipids in allosteric modulation of dopamine D2 receptor - in silico study. Molecules 2022, 27, 1335.
Katarzyna M. Targowska-Duda, Maciej Maj, Piotr Draczkowski, Barbara Budzynska, Anna Boguszewska-Czubara, Tomasz M. Wrobel, Tuomo Laitinen, Patrycja Kaczmar, Antti Poso, Agnieszka A. Kaczor: Acetylcholinesterase inhibitors identified in structure-based virtual screening. ChemMedChem 2022, in press.
Justyna Zuk, Damian Bartuzi, Andrea G. Silva, Monika Pitucha, Oliwia Koszla, Tomasz M. Wrobel, Dariusz Matosiuk, Marian Castro, Agnieszka A. Kaczor: Allosteric modulation of dopamine D2L receptor in complex with Gi1 and Gi2 proteins: the effect of subtle structural and stereochemical ligand modifications. Pharmacol. Rep. 2022, 74, 406-424.
Agata Zieba, Piotr Stepnicki, Dariusz Matosiuk, Agnieszka A. Kaczor: Overcoming depression with 5-HT2A receptor ligands. Int. J. Mol. Sci. 2022, 23, 10.
Damian Bartuzi, Agnieszka A. Kaczor, Dariusz Matosiuk: Illuminating the ‘twilight zone’ – advances in difficult protein modeling. Methods Mol. Biol. 2022, in press.
Agnieszka A. Kaczor, Karolina Wojtunik-Kulesza, Tomasz M. Wrobel, Dariusz Matosiuk, Monika Pitucha: 5-Methoxy-1-methyl-2-{[4-(2-hydroxy phenyl)piperazin-1-yl]methyl}-1H-indole (KAD22) with antioxidant activity. Lett. Org. Chem. 2022, 19, 263-275.
Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Lab, Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, 4A Chodzki St., PL-20093 Lublin, Poland
Google Scholar: Agnieszka A. Kaczor
Researcher ID: A-3744-2015
Orcid: 0000-0001-8679-9623