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Dr. habil. Agnieszka A. Kaczor

Publications


Piotr Stepnicki, Magda Kondej, Oliwia Koszla, Justyna Zuk, Agnieszka A. Kaczor: Multi-targeted drug design strategies for the treatment of schizophrenia. Expert Opin. Drug Discov. 2020, in press.

Oliwia Koszla, Magda Kondej, Piotr Stepnicki, Justyna Zuk, Agnieszka A. Kaczor: Neurogenesis and neuroprotection in the hippocampus as the target to treat central nervous system diseases [Polish]. Science and Industry - Lublin Student Meetings, Maria Curie-Sklodowska University, 2020, in press.

Justyna Zuk, Oliwia Koszla, Magda Kondej, Piotr Stepnicki, Agnieszka A. Kaczor: Dopaminergic disturbances in the pathomechanism of schizophrenia [Polish]. Science and Industry - Lublin Student Meetings, Maria Curie-Sklodowska University, 2020, in press.

Piotr Stepnicki, Magda Kondej, Oliwia Koszla, Justyna Zuk, Anna Kozak, Tomasz M. Wrobel, Agnieszka A. Kaczor: D2AAK2 - a new non-basic ligand of G protein-coupled receptors as a potential antipsychotic [Polish]. Science and Industry - Lublin Student Meetings, Maria Curie-Sklodowska University, 2020, in press.

Magda Kondej, Piotr Stepnicki, Oliwia Koszla, Justyna Zuk, Agata Bartyzel, Tomasz M. Wrobel, Andrea G. Silva, Maria I. Loza, Marian Castro, Dariusz Matosiuk, Agnieszka A. Kaczor: Multi-target ligands of aminergic G protein-coupled receptors [Polish]. Science and Industry - Lublin Student Meetings, Maria Curie-Sklodowska University, 2020, in press.

Damian Bartuzi, Tomasz M. Wrobel, Agnieszka A. Kaczor, Dariusz Matosiuk: Tuning down the pain – an overview of allosteric modulation of opioid receptors: mechanisms of modulation, allosteric sites, modulator syntheses. Curr. Topics Med. Chem. 2020, in press.

Damian Bartuzi, Agnieszka A. Kaczor, Dariusz Matosiuk: Illuminating the ‘twilight zone’ – advances in difficult protein modeling. Methods Mol. Biol. 2020, in press.

Monika Pitucha, Monika Janeczko, Katarzyna Klimek, Emilia Fornal, Maciej Wos, Anna Pachuta-Stec, Grazyna Ginalska, Agnieszka A. Kaczor: 1,2,4-Triazolin-5-thione derivatives with anticancer activity as CK1γ kinase inhibitors. Bioorg. Chem. 2020, in press.

Agnieszka A. Kaczor, Katarzyna M. Targowska-Duda, Andrea G. Silva. Magda Kondej, Grazyna Biala, Marian Castro: N-(2-hydroxyphenyl)-1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidine-4-carboxamide (D2AAK4), a multi-target ligand of aminergic GPCRs, as a potential antipsychotic. Biomolecules 2020, 10, 349.

Monika Pitucha, Agnieszka Korga-Plewko, Pawel Kozyra, Mariola Iwan, Agnieszka A. Kaczor: 2,4-Dichlorophenoxyacetic thiosemicarbazides as a new class of compounds against stomach cancer potentially intercalating with DNA. Biomolecules 2020, 10, 296.

Oliwia Koszla, Katarzyna M. Targowska-Duda, Ewa Kedzierska, Agnieszka A. Kaczor: In vitro and in vivo models for the investigation of potential drugs against schizophrenia. Biomolecules 2020, 10, 160.

Justyna Zuk, Damian Bartuzi, Dariusz Matosiuk, Agnieszka A. Kaczor: Preferential coupling of dopamine D2S and D2L receptor isoforms with Gi1and Gi2 proteins - in silico study. Int. J. Mol. Sci. 2020, 21, 436.

Marta Halasa, Damian Bartuzi, Dominika Cieslak, Agnieszka A. Kaczor, Paulina Miziak, Andrzej Stepulak, Dariusz Matosiuk: Role of N-terminus in function and dynamics of Sirtuin 7 – an in silico study. J. Biomol. Struct. Dyn. 2020, 38, 1283-1291.

Agata Zieba, Justyna Zuk, Damian Bartuzi, Dariusz Matosiuk, Antti Poso, Agnieszka A. Kaczor: The universal 3D QSAR model for dopamine D2 receptor antagonists. Int. J. Mol. Sci. 2019, 20, 4555.

Ewa Habza-Kowalska, Agnieszka A. Kaczor, Justyna Zuk, Dariusz Matosiuk, Urszula Gawlik-Dziki: Thyroid peroxidase activity is inhibited by phenolic compounds – impact of interaction. Molecules 2019, 24, pii: E2766.

Magda Kondej, Tomasz M. Wrobel, Andrea G. Silva, Piotr Stepnicki, Oliwia Koszla, Ewa Kedzierska, Agata Bartyzel, Grazyna Biala, Dariusz Matosiuk, Maria I. Loza, Marian Castro, Agnieszka A. Kaczor: Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs. Eur. J. Med. Chem. 2019, 80, 673-689.

Justyna Zuk, Magda Kondej, Piotr Stepnicki, Oliwia Koszla, Agnieszka A. Kaczor: New approaches in the drugs design acting on the GPCRs, [Polish], Wydawnictwo Tygiel, Lublin 2019, p. 136-143.

Magda Kondej, Piotr Stepnicki, Justyna Zuk, Oliwia Koszla, Agnieszka A. Kaczor: Synthesis, properties and use of indole and its derivatives in medicinal chemistry, [Polish], Wydawnictwo Tygiel, Lublin 2019, p. 41-48.

Piotr Stepnicki, Magda Kondej, Oliwia Koszla, Justyna Zuk, Agnieszka A. Kaczor: Serotonin and drugs affecting serotonergic transmission, [Polish], Wydawnictwo Tygiel, Lublin 2019, p. 144-151.

Oliwia Koszla, Magda Kondej, Piotr Stepnicki, Justyna Zuk, Agnieszka A. Kaczor: Selected in vitro models for the study of neurodegenerative disorders, [Polish], Wydawnictwo Tygiel, Lublin 2019, p. 124-132.

Elisa Magli, Ewa Kedzierska, Agnieszka A. Kaczor, Beatrice Severino, Angela Corvino, Elisa Perissutti, Francesco Frecentese, Paola Massarelli, Jolanta Orzelska-Gorka, Vincenzo Santagada, Giuseppe Caliend, Ferdinando Fiorino: Synthesis, docking studies and pharmacological evaluation of 5HT2C ligands containing N’-cyanoisonicotinamidine or N’-cyanopicolinamidine nucleus. Arch. Pharm. 2019, 352, e1800373.

Piotr Stepnicki, Magda Kondej, Justyna Zuk, Agnieszka A. Kaczor: Dopamine as a neurotransmitter and its receptors [Polish], Wydawnictwo Mlodzi Naukowcy, Poznan 2019, p.160-165.

Magda Kondej, Piotr Stepnicki, Justyna Zuk, Agnieszka A. Kaczor: Alzheimer's disease: neurotransmission in the glutamatergic system [Polish], Wydawnictwo Mlodzi Naukowcy, Poznan 2019, p. 70-78.

Justyna Zuk, Magda Kondej, Piotr Stepnicki, Agnieszka A. Kaczor: In silico methods in GPCR receptor research, [Polish], Wydawnictwo Mlodzi Naukowcy, Poznan 2019, p. 140-145.

Piotr Stepnicki, Justyna Zuk, Magda Kondej, Agnieszka A. Kaczor: Parkinson's disease - pathomechanism and treatment, [Polish], Wydawnictwo Mlodzi Naukowcy, Poznan 2019, p. 166-171.

Magda Kondej, Piotr Stepnicki, Justyna Zuk, Agnieszka A. Kaczor: Microwaves as a modern technique used in organic synthesis, [Polish], Wydawnictwo Mlodzi Naukowcy, Poznan 2019, p. 21-28.

Justyna Zuk, Magda Kondej, Piotr Stepnicki, Agnieszka A. Kaczor: Disorders of the dopaminergic system in neurodegenerative diseases, [Polish], Wydawnictwo Mlodzi Naukowcy, Poznan 2019, p. 146-151.

Katarzyna Targowska-Duda, Agnieszka A. Kaczor, Krzysztof Jozwiak, Hugo R. Arias: Molecular interactions of type I and type II positive allosteric modulators with the human α7 nicotinic acetylcholine receptor: An in silico study. J. Biomol. Struct. Dyn. 2019, 31, 411-439.

Damian Bartuzi, Agnieszka A. Kaczor, Dariusz Matosiuk: Molecular mechanisms of allosteric probe dependence in µ opioid receptor. J. Biomol. Struct. Dyn. 2019, 31, 36-47.

Magda Kondej, Piotr Stepnicki, Agnieszka A. Kaczor: Multi-target approach for drug discovery against schizophrenia. Int. J. Mol. Sci. 2018, 19, pii: E3105.

Magda Kondej, Agata Bartyzel, Monika Pitucha, Tomasz M. Wrobel, Andrea G. Silva, Dariusz Matosiuk, Marian Castro, Agnieszka A. Kaczor: Synthesis, structural and thermal studies of 3-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1H-indole (D2AAK1_3) as dopamine D2 receptor ligand. Molecules 2018, 23, pii: E2249.

Piotr Stepnicki, Magda Kondej, Agnieszka A. Kaczor: Current concepts and treatments of schizophrenia. Molecules 2018, 23, pii: E2087.

Marta Swatko-Ossor, Katarzyna Klimek, Anna Belcarz, Agnieszka A. Kaczor, Monika Pitucha, Grazyna Ginalska: Do new N-substituted 3-amino-4-phenyl-5-oxo-pyrazolinecarboxamide derivatives exhibit antitubercular potential? Eur. J. Pharm. Sci. 2018, 121, 155-165.

Agata Bartyzel, Agnieszka A. Kaczor, Halina Gluchowska, Monika Pitucha, Tomasz M. Wrobel, Dariusz Matosiuk:Thermal and spectroscopic studies of 2,3,5-trisubstituted and 1,2,3,5-tetrasubstituted indoles as non-competitive antagonists of GluK1/GluK2 receptors. J. Therm. Anal. Calorim. 2018, 133, 935-944.

Agnieszka A. Kaczor, Justyna Zuk, Dariusz Matosiuk: Comparative Molecular Field Analysis and molecular dynamics studies of the dopamine D2 receptor antagonists without a protonatable nitrogen atom. Med. Chem. Res. 2018, 27, 1149-1166.

Agnieszka A. Kaczor, Prasanthi Medarametla, Damian Bartuzi, Magdalena Kondej, Dariusz Matosiuk, Antti Poso: Molecular modelling approaches to antibacterial drug design and discovery. Frontiers in Anti-Infective Drug Discovery 2018, in press.

Agata Bartyzel, Agnieszka A. Kaczor: Synthesis, crystal structure, thermal, spectroscopic and theoretical studies of N3O2-donor Schiff base and its complex with CuII ions. Polyhedron 2018, 139, 271-281.

Malgorzata Miazga-Karska, Maciej Wos, Agnieszka A. Kaczor, Anna Pachuta-Stec, Grazyna Ginalska, Monika Pitucha: Inhibitory effects of 1,4-disubstituted thiosemicarbazide derivatives on Streptococcus mutans and Streptococcus sanguinis mono-species biofilms. Lett. Drug Design Discover. 2018, 15, 843-850.

Agnieszka A. Kaczor, Agata Bartyzel, Monika Pitucha, Tomasz M. Wrobel, Sylwia Wozniak, Dariusz Matosiuk: Synthesis, experimental and computational studies of N-(4-amino-6-oxo-1,6-dihydropyrimidin-5-yl)benzamide. Lett. Org. Chem. 2018, 15, 491-502.

Agnieszka A. Kaczor, Damian Bartuzi, Tomasz Maciej Stepniewski, Dariusz Matosiuk, Jana Selent: Protein-protein docking in drug design and discovery. Methods Mol. Biol. 2018, 1762, 285-305.

Ismael Rodríguez-Espigares, Agnieszka A. Kaczor, Tomasz Maciej Stepniewski, Jana Selent: Challenges and opportunities in drug discovery of biased ligands. Methods Mol. Biol. 2018, 705, 321-334

Damian Bartuzi, Agnieszka A. Kaczor, Dariusz Matosiuk: Opportunities and challenges in the discovery of allosteric modulators of GPCRs. Methods Mol. Biol. 2018, 1705, 297-319.

Maciej Wos, Małgorzata Miazga-Karska, Agnieszka A. Kaczor, Katarzyna Klimek, Zbigniew Karczmarzyk, Dorota Kowalczuk, Waldemar Wysocki, Grazyna Ginalska, Zofia Urbanczyk-Lipkowska, Maja Morawiak, Monika Pitucha: Novel thiosemicarbazide derivatives with 4-nitrophenyl group as multi-target drugs: α-glucosidase inhibitors with antibacterial and antiproliferative activity. Biomed. Pharmacother. 2017, 93, 1269-1276.

Damian Bartuzi, Agnieszka A. Kaczor, Dariusz Matosiuk: Signaling within allosteric machines: signal transmission pathways inside G protein-coupled receptors. Molecules 2017, 22, E1188.

Damian Bartuzi, Agnieszka A. Kaczor, Katarzyna M. Targowska-Duda, Dariusz Matosiuk: Recent advances and applications of molecular docking to G protein-coupled receptors. Molecules 2017, 22, E340.

Agnieszka A. Kaczor, Karolina Sobotka-Polska, Andrzej Polski, Magdalena Makarska-Bialokoz, Anna Pachuta-Stec, Monika Pitucha: Novel antibacterial compounds and their targets – successes and challenges. Curr. Med. Chem. 2017, 24, 1948-1982.

Agnieszka A. Kaczor, Manuela Jörg, Ben Capuano: The dopamine D2 receptor dimer and its interaction with homobivalent antagonists: homology modeling, docking and molecular dynamics. J. Mol. Model. 2016, 22, 203.

Hugo R. Arias, Federica Ravazzini, Katarzyna M. Targowska-Duda, Agnieszka A. Kaczor, Dominik Feuerbach, Juan C. Boffi, Piotr Draczkowski, Dirk Montag, Brandon M. Brown, Ana Belén Elgoyhen, Krzysztof Jozwiak, Giulia Puia: Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content. Int. J. Biochem. Cell Biol. 2016, 76, 19-30.

Damian Bartuzi, Agnieszka A. Kaczor, Dariusz Matosiuk: Interplay between two allosteric sites and their influence on agonist binding in human μ opioid receptor. J. Chem. Inf. Model. 2016, 56, 563-570.

Elzbieta Szacon, Marzena Rzadkowska, Agnieszka A. Kaczor, Ewa Kedzierska, Jolanta Orzelska-Gorka, Sylwia Fidecka, Dariusz Matosiuk: Synthesis and pharmacological evaluation of novel 1-(1,4-alkylaryldisubstituted-4,5-dihydro-1H-imidazo)-3-substituted urea derivatives. Molecules 2016, 21, 582.

Jolanta Flieger, Malgorzata Tatarczak-Michalewska, Anna Kowalska, Marzena Rzadkowska, Elzbieta Szacon, Agnieszka A. Kaczor, Dariusz Matosiuk: Fragmental method KowWIN as the powerful tool for prediction of chromatographic behavior of novel bioactive urea derivative. J. Braz. Chem. Soc., 2016, 27, 2312-2321.

Agnieszka A. Kaczor, Katarzyna M. Targowska-Duda, Barbara Budzynska, Grazyna Biala, Andrea G. Silva, Marian Castro: In vitro, molecular modeling and behavioral studies of 3-{[4-(5-methoxy-1H-indol-3-yl)-1,2,3,6-tetrahydropyridin-1-yl]methyl}-1,2-dihydroquinolin-2-one (D2AAK1) as a potential antipsychotic. Neurochem. Int., 2016, 96, 84-99.

Damian Bartuzi, Agnieszka A. Kaczor, Dariusz Matosiuk: Interplay between two allosteric sites and their influence on agonist binding in human μ opioid receptor. J. Chem. Inf. Model. 2016, 56, 563-570.

Agnieszka A. Kaczor, Andrea G. Silva, Maria I. Loza, Peter Kolb, Marian Castro, Antti Poso: Structure-based virtual screening for dopamine D2 receptor ligands as potential antipsychotics. ChemMedChem 2016, 11, 718-729.

Marzena Rzadkowska, Elzbieta Szacon, Agnieszka A. Kaczor, Barbara Rajtar, Lukasz Swiatek, Malgorzata Polz-Dacewicz, Dariusz Matosiuk: Synthesis, antiviral activity and structure-activity relationship of 1-(1-aryl-4,5-dihydro-1H-imidazoline)-3-chlorosulfonylureas and products of their cyclization. J. Enzyme Inhib. Med. Chem. 2016, 31, 787-795.

Tomasz M. Wrobel, Michal Kielbus, Agnieszka A. Kaczor, Vladimir Krystof, Zbigniew Karczmarzyk, Waldemar Wysocki, Andrzej Fruzinski, Sylwia K. Krol, Aneta Grabarska, Andrzej Stepulak, Dariusz Matosiuk: Discovery of nitroaryl urea derivatives with antiproliferative properties. J. Enzyme Inhib. Med. Chem. 2016, 31, 608-618.

Marzena Rzadkowska, Elzbieta Szacon, Agnieszka A. Kaczor, Barbara Rajtar, Lukasz Swiatek, Malgorzata Polz-Dacewicz, Dariusz Matosiuk: Synthesis and antiviral activity of 1-(1,3-disubstitutedimidazolidyn-2-ylidene)-3-ethoxycarbonylmethylurea derivatives. J. Enzyme Inhib. Med. Chem. 2016, 31, 361-368.

Monika Aletanska-Kozak, Agnieszka A. Kaczor, Tomasz Wrobel, Anna E. Koziol, Kinga Suwinska, Izabela Dybala, Kalevi Pihlaja, Dariusz Matosiuk: The pseudo-Michael reaction of 2-hydrazinylidene-1-arylimidazolidines with diethyl ethoxymethylenemalonate (DEEM). J. Heterocycl. Chem. 2016, 53, 571-578.

Agnieszka A. Kaczor, Ewelina Rutkowska, Damian Bartuzi, Katarzyna M. Targowska-Duda, Dariusz Matosiuk, Jana Selent: Computational methods for studying GPCRs. Methods Cell Biol. 2016,132, 359-399.

Sari Yrjölä, Teija Parkkari, Dina Navia-Paldanius, Tuomo Laitinen, Agnieszka A. Kaczor, Tarja Kokkola, Frank Adusei-Mensah, Juha R. Savinainen, Jarmo T. Laitinen, Antti Poso, Amy Alexander, June Penman, Lisa Stott, Marie Anskat, Andrew J. Irving, Tapio J. Nevalainen: Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists. Eur. J. Med. Chem. 2016, 107, 119-132.

Monika Pitucha, Karolina Sobotka-Polska, Radoslaw Keller, Anna Pachuta-Stec, Ewaryst Mendyk, Agnieszka A. Kaczor: Synthesis and structure of new 1-cyanoacetyl-4-arylsemicarbazide derivatives with potential anticancer activity. J. Mol. Struct. 2016, 1104, 24-32.

Elzbieta Szacon, Marzena Rzadkowska, Agnieszka A. Kaczor, Ewa Kedzierska, Antonina Mazur, Sylwia Fidecka, Dariusz Matosiuk: Synthesis, central nervous system activity and structure-activity relationship of N-substituted derivatives of 1-arylimidazolidyn-2-ylideneurea and products of their cyclization. J. Enzyme Inhib. Med. Chem. 2015, 30, 746-760.

Jayendra Z. Patel, John van Bruchem, Tuomo Laitinen, Agnieszka A. Kaczor, Dina Navia-Paldanius, Teija Parkkari, Juha R. Savinainen, Jarmo T. Laitinen, Tapio J. Nevalainen: Revisiting 1,3,4-oxadiazol-2-ones: utilization in the development of ABHD6 inhibitors. Bioorg. Med. Chem. 2015, 23, 6335-6345.

Damian Bartuzi, Agnieszka A. Kaczor, Dariusz Matosiuk: Activation and allosteric modulation of human μ opioid receptor in molecular dynamics. J. Chem. Inf. Model. 2015, 55, 2421-2434.

Agata Bartyzel, Agnieszka A. Kaczor: The formation of a neutral manganese(III) complex containing a tetradentate Schiff base and ketone: synthesis and characterization. J. Coord. Chem. 2015, 68, 3701-3717.

Agnieszka A. Kaczor, Katarzyna M. Targowska-Duda, Jayendra Z. Patel, Tuomo Laitinen, Teija Parkkari, Yahaya Adams, Tapio J. Nevalainen, Antti Poso: Comparative Molecular Field Analysis and molecular dynamics studies of α/β hydrolase domain containing 6 (ABHD6) inhibitors. J. Mol. Model. 2015, 21, 2789.

Tomasz M. Wrobel, Urszula Kosikowska, Agnieszka A. Kaczor, Sylwia Andrzejczuk, Zbigniew Karczmarzyk, Waldemar Wysocki, Zofia Urbanczyk-Lipkowska, Maja Morawiak, Dariusz Matosiuk: Synthesis, structural studies and molecular modelling of novel imidazoline derivative with antifungal activity. Molecules 2015, 20, 14761-14776.

Agnieszka A. Kaczor, Ramon Guixa-González, Pau Carrio, Antti Poso, Stefan Dove, Manuel Pastor, Jana Selent: Multi-component protein-protein docking based protocol with external scoring for modeling dimers of G protein-coupled receptors. Mol. Inform. 2015, 34, 246-255.

Elzbieta Szacon, Marzena Rzadkowska, Agnieszka A. Kaczor, Ewa Kedzierska, Sylwia Fidecka, Dariusz Matosiuk: Synthesis, central nervous system activity and structure-activity relationship of novel 1-(1-alkyl-4-aryl-4,5-dihydro-1H-imidazo)-3-substituted urea derivatives. Molecules 2015, 20, 3821-3840.

Maria Marti-Solano, Agnieszka A. Kaczor, Ramon Guixa-González, Jana Selent: Computational Strategies to Incorporate GPCR Complexity in Drug Design, [in:] Frontiers in Computational Chemistry, 2015, 1, 3-43.

Agnieszka A. Kaczor, Tomasz Wrobel, Christiane Kronabach, Klaus Unverferth, Tomasz Stachal, Dariusz Matosiuk: Synthesis and molecular docking of novel non-competitive antagonists of GluK2 receptor. Med. Chem. Res. 2015, 4, 810-817.

Andrzej Polski, Agnieszka A. Kaczor, Karolina Sobotka-Polska, Monika Pitucha: From synthesis and spectral analysis to molecular modeling – multidimensional teaching of medicinal chemistry: aspirin as an example. Indian J. Pharm. Educ. 2015, 49, 82-86.

Hugo R. Arias, Dominik Feuerbach, Katarzyna Targowska-Duda, Agnieszka A. Kaczor, Antti Poso, and Krzysztof Jozwiak: Pharmacological and molecular studies on the interaction of varenicline with different nicotinic acetylcholine receptor subtypes. Biochim. Biophys. Acta – Biomembranes 2015, 1848, 731-741.

Jayendra Z. Patel, Tapio J. Nevalainen, Juha R. Savinainen, Yahaya Adams, Tuomo Laitinen, R. Scott Runyon, Miia Vaara, Stephen Ahenkorah, Agnieszka A. Kaczor, Dina Navia-Paldanius, Mikko Gynther, Niina Aaltonen, Amit A. Joharapurkar, Mukul R. Jain, Abigail S. Haka, Frederick R. Maxfield, Jarmo T. Laitinen, Teija Parkkari: Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. ChemMedChem 2015, 10, 253-265.

Magdalena Makarska-Bialokoz, Agnieszka A. Kaczor: Computational analysis of chlorophyll structure and UV-VIS spectra – the student research project concerning the spectroscopy of natural complexes, Spectr. Lett. 2014, 47, 147-152.

Agnieszka A. Kaczor, Zbigniew Karczmarzyk, Andrzej Fruziński, Kalevi Pihlaja, Jari Sinkkonen, Kirsti Wiinamaki, Christiane Kronbach, Klaus Unverferth, Antti Poso, Dariusz Matosiuk: Structural studies, homology modeling and molecular docking of novel non-competitive antagonists of GluK1/GluK2 receptors. Bioorg. Med. Chem. 2014, 22, 787-795.

Agnieszka A. Kaczor, Tomasz Wróbel, Zbigniew Karczmarzyk, Waldemar Wysocki, Andrzej Fruziński, Małgorzata Brodacka, Dariusz Matosiuk, Monika Pitucha: Structural studies on N-(1-naphthyl)-3-amino-5-oxo-4-phenyl-1H-pyrazole-1-carboxamide with antibacterial activity. Lett. Org. Chem. 2014, 11, 40-48.

Marzena Rzadkowska, Elzbieta Szacon, Agnieszka A. Kaczor, Sylwia Fidecka, Ewa Kedzierska, Dariusz Matosiuk: Synthesis, pharmacological activity and molecular modeling of 1-aryl-7-hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1H)-ones and their 6-substituted derivatives. Med. Chem. 2014, 10, 460-475.

Marzena Rzadkowska, Elzbieta Szacon, Agnieszka A. Kaczor, Sylwia Fidecka, Ewa Kedzierska, Dariusz Matosiuk: Synthesis, central nervous system activity and structure-activity relationship of 1-aryl-6-benzyl-7-hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1H)-ones. Med. Chem. Res. 2014, 23, 4221-4423.

Agnieszka A. Kaczor, Kalevi Pihlaja, Jari Sinkkonen, Kirsti Wiinämaki, Christiane Kronbach, Klaus Unverferth, Tomasz Wróbel, Tomasz Stachal, Dariusz Matosiuk: Synthesis and molecular docking of indole and carbazole derivatives with potential pharmacological activity. Heterocycl. Comm. 2014, 20, 103-109.

Agnieszka A. Kaczor, Monika Aletanska-Kozak, Tomasz Wróbel: Synthesis, experimental and computational spectroscopic studies, and formation thermodynamics of diethyl [[2-(1-Aryl-4,5-dihydro-1H-imidazol- 2-yl)hydrazinyl]methylene]propanedioates. Lett. Org. Chem. 2014, 11, 493-497.

Agnieszka A. Kaczor, Magdalena Makarska-Białokoz, Jana Selent, Rocio A. de la Fuente, Maria Marti-Solano, Marian Castro: Application of BRET for studying G protein-coupled receptors. Mini Rev. Med. Chem. 2014, 14, 411-425.

Manuela Jorg, Agnieszka A. Kaczor, Frankie S. Mak, Kiew Ching K. Lee, Antti Poso, Neil D. Miller, Peter J. Scammells, Ben Capuano: Investigation of novel ropinirole analogues: synthesis, pharmacological evaluation and computational analysis of dopamine D2 receptor functionalized congeners and homobivalent ligands. MedChemComm 2014, 5, 891-898.

Agnieszka A. Kaczor, Antti Poso, Monika Pitucha: In vitro screening of some heterocyclic compounds against human ABHD6 and ABHD12 hydrolases. Lett. Drug Design Discov. 2014, 11, 944-952.

Agnieszka A. Kaczor, Damian Bartuzi, Dariusz Matosiuk: Modeling the active conformation of human  opioid receptor. Lett. Drug Design Discov. 2014, 11, 1053-1061.

Krzysztof Jozwiak, Katarzyna M. Targowska-Duda, Agnieszka A. Kaczor (shared 1st authorship), Joanna Kozak, Agnieszka Ligeza, Elzbieta Szacon, Tomasz Wrobel, Barbara Budzynska, Grazyna Biala, Emilia Fornal, Antti Poso, Irving W. Wainer, Dariusz Matosiuk: Synthesis, in vitro and in vivo studies, and molecular modeling of N-alkylated dextromethorphan derivatives as non-competitive inhibitors of α3β4 nicotinic acetylcholine receptor. Bioorg. Med. Chem. 2014, 22, 6846-6856.

Agnieszka A. Kaczor, Maria Marti-Solano, Ramon Guixà-González, Jana Selent: Recent Progress in Modeling G Protein-Coupled Receptors, [in:] Bioinformatics, J. Govil (ed.), Studium Press LLC 2014, Houston, USA.

Karolina Sobotka-Polska, Agnieszka A. Kaczor, Robert Keller, Ewaryst Mendyk, Anna Pachuta- Stec, Andrzej Polski, Monika Pitucha: Spectroscopic Studies of Novel Derivatives of 1-Cyanoacetyl-4-arylsemicarbazide, [Polish] [in:] Science and industry – spectroscopic methods in practice, new challenges and possibilities. Zbigniew Hubicki (ed.), Lublin 2014, M. Curie-Sklodowska University, Lublin, Faculty of Chemistry.

Agnieszka A. Kaczor, Monika Pitucha, Zbigniew Karczmarzyk, Waldemar Rzymowski, Jolanta Rzymowska, Dariusz Matosiuk: Structural and molecular docking studies of 4-benzyl-3-[(1-methylpyrrol-2-yl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one with anticancer activity. Med. Chem. 2013, 9, 313-328.

Jana Selent, Agnieszka A. Kaczor (shared 1st authorship), Ramon Guixa-Gonzalez, Pau Carrio, Manuel Pastor, Cristian Obiol Pardo: Rational design of the survivin/CDK4 complex by combining protein-protein docking and molecular dynamics simulations, J. Mol. Model. 2013, 19, 1507-1514

Agnieszka A. Kaczor, Urszula Kijkowska-Murak, Kalevi Pihlaja, Jari Sinkkonen, Waldemar Wysocki, Zbigniew Karczmarzyk, Dariusz Matosiuk: The pseudo-Michael reaction of 1-aryl-2-aminoimidazolines-2 with ethyl ethoxymethylenecyanoacetate (EMCA). Monat. Chem. 2013, 144, 1171-1182.

Agnieszka A. Kaczor, Jana Selent, Ferran Sanz, Manuel Pastor: Modeling complexes of transmembrane proteins: systematic analysis of protein-protein docking tools, Mol. Inform. 2013, 32, 717-733.

Jayendra Z. Patel, Teija Parkkari, Tuomo Laitinen, Agnieszka A. Kaczor, Susanna M. Saario, Juha R. Savinainen, Dina Navia-Paldanius, Maria Teresa Cipriano, Jukka Leppänen, Igor O. Koshevoy, Antti Poso, Christopher J. Fowler, Jarmo T. Laitinen, Tapio Nevalainen: Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors. J. Med. Chem. 2013, 56, 8484-8496.

Agnieszka A. Kaczor, Tomasz Wróbel, Zbigniew Karczmarzyk, Waldemar Wysocki, Ewaryst Mendyk, Antti Poso, Dariusz Matosiuk, Monika Pitucha: Experimental and computational studies on the tautomerism of N-substituted 3-amino-5-oxo-4-phenyl-1H-pyrazolo-1-carboxamides with antibacterial activity. J. Mol. Struct. 2013, 1051, 188-196.

Agnieszka A. Kaczor, Jana Selent, Antti Poso: Structure-based Molecular Modeling Approaches to GPCR Oligomerization, Methods Cell Biol. 2013, 117, 91-104.

Ramon Guixa-Gonzalez, Juan Manuel Ramirez-Anguita, Agnieszka A. Kaczor, Jana Selent: Simulating G Protein-Coupled Receptors in Native-Like Membranes: from Monomers to Oligomers. Methods Cell Biol. 2013, 117, 63-90.

Agnieszka A. Kaczor, Tomasz Wrobel, Zbigniew Karczmarzyk, Ewaryst Mendyk, Waldemar Wysocki, Dariusz Matosiuk, Monika Pitucha: Theory and Experiment in the Spectroscopic Studies on the Tautomerism of Antibacterial Pirazolones, [Polish] [in:] Science and industry – spectroscopic methods in practice, new challenges and possibilities. Zbigniew Hubicki (ed.), Lublin 2013, M. Curie-Sklodowska University, Lublin, Faculty of Chemistry.

Monika Pitucha, Agnieszka A. Kaczor, Waldemar Wysocki, Anna Pachuta-Stec, Zbigniew Karczmarzyk: Spectroscopic studies of some heterocyclic compounds with antibacterial activity, [Polish] [in:] Science and industry – spectroscopic methods in practice, new challenges and possibilities. Zbigniew Hubicki (ed.), Lublin 2013, M. Curie-Sklodowska University, Lublin, Faculty of Chemistry.

Monika Pitucha, Anna Pachuta Stec, Agnieszka A. Kaczor: New five-membered ring heterocyclic compounds with antibacterial and antifungal activity. [in:] Microbial pathogens and strategies for combating them: science, technology and education. Vol. 1. A. Méndez-Vilas (ed.), Badajoz 2013, Formatex Research Center, p. 562-573, Microbiology Book Series.

Agnieszka A. Kaczor, Ramon Guixa-Gonzalez, Pau Carrio, Cristian Obiol-Pardo, Manuel Pastor, Jana Selent: Fractal dimension as a measure of surface roughness of G protein-coupled receptors: implications for structure and function, J. Mol. Model. 2012, 18, 4465-4475.

Agnieszka A. Kaczor, Christiane Kronbach, Klaus Unverferth, Kalevi Pihlaja, Kirsti Wiinamaki, Jari Sinkkonen, Urszula Kijkowska-Murak, Tomasz Wrobel, Tomasz Stachal, Dariusz Matosiuk: Novel non-competitive antagonists of kainate GluK1/GluK2 receptors, Lett. Drug Design Discov. 2012, 9, 891-898.

Monika Pitucha, Zbigniew Karczmarzyk, Waldemar Wysocki, Agnieszka A. Kaczor, Dariusz Matosiuk: Experimental and theoretical investigations on the keto-enol tautomerism of 4-substituted 3-[1-methylpyrrol-2-yl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one derivatives, J. Mol. Struct. 2011, 994, 313-320.

Agnieszka A. Kaczor, Jana Selent: Oligomerization of G protein-coupled receptors: biochemical and biophysical methods, Curr. Med. Chem. 2011, 18, 4606-4634, (invited review).

Jana Selent, Agnieszka A. Kaczor: Oligomerization of G protein-coupled receptors: computational methods, Curr. Med. Chem. 2011, 18, 4588-4605, (invited review).

Agnieszka A. Kaczor: Computer-assisted classes on medicinal chemistry of barbiturates and thiobarbiturates, Probl. Educ. 21st Century 2011, 28, 61-71.

Agnieszka A. Kaczor: Computer-assisted classes on medicinal chemistry of neuroleptics, Probl. Educ. 21st Century 2011, 28, 49-60.

Agnieszka A. Kaczor, Adam Kaczor: Sulfur in Medicine [Polish], [in:] Elements in Environment and Medicine. Jackowska I. (ed.), Radom 2011, Instytut Naukowo-Wydawniczy "Spatium", p. 339-358.

Adam Kaczor, Agnieszka A. Kaczor: Sulfur in Environment, [Polish], [in:] Elements in Environment and Medicine. Jackowska I. (ed.), Radom 2011, Instytut Naukowo-Wydawniczy "Spatium", p. 97-115.

Agnieszka A. Kaczor, Dariusz Matosiuk: Structure-based virtual screening for novel inhibitors of Japanese encephalitis virus NS3 helicase/nucleoside triphosphatase, FEMS Immunol. Med. Microbiol. 2010, 58, 91-101.

Agnieszka A. Kaczor, Dariusz Matosiuk: Molecular structure of ionotropic glutamate receptors, Curr. Med. Chem. 2010, 17, 2608-2635, (invited review).

Agnieszka A. Kaczor, Urszula Kijkowska-Murak, Christiane Kronbach, Klaus Unverferth, Dariusz Matosiuk: Modeling of glutamate GluR6 receptor and its interactions with novel non-competitive antagonists, J. Chem. Inf. Model., 2009, 49, 1094-1104.

Agnieszka A. Kaczor, Dariusz Matosiuk, Andrzej Persona: Teaching protein science with application of computers – case study of BCL-2 protein family, Probl. Educ. 21st Century 2009, 11, 69-67.

Marek Persona, Andrzej Persona, Tomasz Geca, Agnieszka A. Kaczor, Dariusz Matosiuk: Computers in medicinal chemistry. molecular modeling and calculation of the structure-correlated parameters describing skin permeability of tea flavonoids, Probl. Educ. 21st Century 2009, 11, 139-150.

Agnieszka A. Kaczor, Dariusz Matosiuk, Andrzej Persona: Computer Classes on Computer-Assisted Drug Design. Case Studies: Estimation of Drug-Likeness and Calculation of ADMET Properties for Novel Non-competitive GluR5/6 Receptors Antagonists [in:] Research, Theory and Practice in Chemistry Didactics. 2nd Part: Overview Studies and Short Information, Hradec Králové 2009, Gaudeamus, p. 316-326.

Agnieszka A. Kaczor, Dariusz Matosiuk, Andrzej Persona: Computer Classes on Computer-Assisted Drug Design. Case Studies: Virtual Screening Towards Novel Monoamine Oxidase B (MAO-B) Inhibitors [in:] Research, Theory and Practice in Chemistry Didactics. 2nd Part: Overview Studies and Short Information, Hradec Králové 2009, Gaudeamus, p. 306-315.

Agnieszka A. Kaczor, Urszula Kijkowska-Murak, Dariusz Matosiuk: Theoretical studies on the structure and symmetry of the transmembrane region of glutamatergic GluR5 receptor, J. Med. Chem. 2008, 51, 3765-3776.

Waldemar Wysocki, Dariusz Matosiuk, Zbigniew Karczmarzyk, Kalevi Pihlaja, Agnieszka A. Kaczor, Urszula Kijkowska-Murak, Zofia Urbañczyk-Lipkowska: Crystal structure of 1-(4-chlorophenyl)-5(1H)-oxo-2,3-dihydroimidazo[1,2-a]-pyrimidine-6-carbonitrile, Anal. Sci.: X-ray Structure Analysis Online, 2008, 24, x119.

Agnieszka A. Kaczor, Urszula Kijkowska-Murak, Dariusz Matosiuk, Andrzej Persona: Computer Classes on Computer-Assisted Drug Design. Case Studies: Histamine Receptor Ligands [in:] Nodzynska, M; Pasko R.J (ed.) Resarch in the Didactics of the Science, Cracow 2008, 186-188.

Agnieszka A. Kaczor, Dariusz Matosiuk: EMCA and DEEM as Michael reagents used in organic synthesis, Curr. Org. Chem. 2005, 9, 1237-1259.

Agnieszka A. Kaczor, Dariusz Matosiuk: Non-peptide Opioid Receptor Ligands - Recent Advances. Part I - Agonists, Frontiers in Medicinal Chemistry - Online, 2004, 1, 477-500.

Agnieszka A. Kaczor, Dariusz Matosiuk: Non-peptide opioid receptor ligands - recent advances. Part I - Agonists, Curr. Med. Chem. 2002, 9, 1567-1589, (invited review).

Agnieszka A. Kaczor, Dariusz Matosiuk: Non-peptide opioid receptor ligands - recent advances. part ii - antagonists, Curr. Med. Chem. 2002, 9, 1591-1603, (invited review).



  
About

Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Lab, Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, 4A Chodzki St., PL-20093 Lublin, Poland

Google Scholar: Agnieszka A. Kaczor
Researcher ID: A-3744-2015
Orcid: 0000-0001-8679-9623


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